Royal Air Force Typhoon FGR4s have operated alongside French warplanes in a joint strike targeting an subterranean weapons facility in Syria employed by the IS group, according to the UK's MoD.
The site, pinpointed through intelligence, was assessed as housing weapons and explosive materials, the release indicated, and was located in mountains just to the north of Palmyra in the heart of Syria.
"The RAF jets used laser-guided Paveway IV weapons to hit a series of entry passages down to the depot... preliminary assessments suggest the strike was effective," the ministry announced.
There was no sign of any civilian impact in the operation on Saturday evening and all the aircraft made a safe return, the defence officials confirmed.
The Typhoon fighters were backed up by a Voyager tanker plane.
Daesh - also known as the so-called Islamic State - imposed militant control over large swathes of Syria and Iraq until 2019.
"This action demonstrates our UK leadership, and commitment to operate in unison with our partners, to eradicate any revival of the terrorist group and their violent and radical beliefs in the region," Britain's Defence Chief the minister said.
British military aircraft have carried out patrols over Syria to "prevent any efforts to regroup" of IS after its routing at the Baghuz confrontation in the year 2019, the authorities noted.
"I extend gratitude to every member of the UK armed forces involved in this operation for their professionalism and their courage," he added. "Including them were thousands of British personnel on duty over the holidays. This action, to eliminate dangerous terrorists who pose a risk to our safety, shows how UK forces are ready to step up, continuously, protecting the UK within its borders and influential overseas."
Last December, the US military executed what it described as a "massive strike" on IS targets in the country, subsequent to an attack claimed the lives of two American soldiers and a civilian linguist in the Palmyra area.
The UN says Islamic State still boasts between 5,000 and 7,000 combatants in Iraq and Syria.
